Prescribed exclusively for adult men, Super Avana combines two active components — Avanafil 100mg and Dapoxetine Hydrochloride 60mg — in a single prescription-only tablet. Both erectile dysfunction and premature ejaculation are the two conditions this medicine uses to treat, making it a dual-action solution for adult men.
Medicine Reference Table
Before starting any new medicine, it helps to understand exactly what you are taking. The table below summarises the key clinical details of Super Avana.
| Property | Detail |
|---|---|
| Active Ingredients | Avanafil 100mg + Dapoxetine Hydrochloride 60mg |
| Drug Classes | PDE5 Inhibitor (Avanafil) + SSRI (Dapoxetine) |
| Prescription Status | Prescription-Only Medicine (POM) |
| Therapeutic Use | Erectile Dysfunction + Premature Ejaculation |
| UK Equivalent Brands | Avanafil: Spedra · Dapoxetine: Priligy |
| Available Strength | 100mg / 60mg Combination Tablet |
| Route of Administration | Oral |
In the UK, Avanafil is individually licensed as Spedra, whilst Dapoxetine is licensed as Priligy. Super Avana delivers both active ingredients in a single tablet, providing a combined therapeutic approach for men experiencing both conditions simultaneously.
Mechanism of Action
Understanding how a medicine works can help you use it correctly and recognise when something may not be right. Super Avana acts through two distinct but complementary pharmacological pathways.
Avanafil: PDE5 Inhibitor
Cyclic guanosine monophosphate (cGMP) is broken down within the corpus cavernosum by an enzyme known as phosphodiesterase type 5 (PDE5). By blocking this enzymatic pathway, Avanafil elevates intracellular cGMP levels, promoting smooth muscle relaxation and increasing arterial blood flow to the penile tissue. The resultant erection occurs only in the presence of sexual stimulation. Avanafil does not produce an erection independently of arousal. Avanafil selectively blocks this enzyme, allowing cGMP to accumulate and support an erection.
Dapoxetine: SSRI
Avanafil selectively blocks this enzyme, allowing cGMP to accumulate and support an erection. Elevated synaptic serotonin activity modulates the ejaculatory reflex, prolonging the time to ejaculation and supporting voluntary ejaculatory control. Dapoxetine has a rapid absorption profile and a short half-life. After the tablet is swallowed, its effects can begin to be felt in as little as 15 to 30 minutes.
Clinical Uses
Both erectile dysfunction and premature ejaculation are the two conditions this medicine uses to treat, making it a dual-action solution for adult men. A prescriber will assess clinical suitability prior to initiation. Conditions where it may be considered include:
Persistent inability to achieve or sustain a satisfactory erection for sexual intercourse. Premature ejaculation that is persistent and causes distress — whether personal or within a relationship — is also an approved indication Co-occurring erectile dysfunction and premature ejaculation, where combination treatment is clinically appropriate Cases in which psychological or psychosomatic factors contribute to both conditions Situations where managing both conditions with a single medicine improves treatment adherence
A thorough medical history, including cardiovascular status, concurrent medicines, and psychological health, must be obtained before prescribing. Women, adolescents, and children must not use this medicine, as it is formulated solely for adult men.
Safety Information
Like all prescription medicines, Super Avana carries a risk of side effects. Not every person who takes this medicine will experience side effects.
Side Effects
Among the side effects reported most frequently are:
| Symptom/Condition | Details | Action Required |
|---|---|---|
| Headache | Pain or pressure in the head | Monitor; consult a doctor if severe or persistent |
| Nausea | Feeling of an urge to vomit | Rest, stay hydrated; seek care if prolonged |
| Dizziness / Light-headedness | Feeling faint, unsteady, or woozy | Sit or lie down; consult a doctor if recurring |
| Priapism | Painful erection lasting more than 4 hours | Seek immediate medical attention without delay |
For best results, the tablet should be taken 15 to 30 minutes ahead of the intended sexual activity.
| Feature | Severe Hypotension | Serotonin Syndrome |
|---|---|---|
| Clinical Term | Severe Hypotension | Serotonin Syndrome |
| Severity | Serious, requires urgent treatment | Rare but serious |
| Key Symptoms | Dangerously low blood pressure | Agitation, confusion, rapid heart rate, high body temperature |
| Onset Nature | Acute/urgent | Rare occurrence |
Important
If you experience any serious adverse effect, stop taking Super Avana immediately. Contact your GP if you notice serious symptoms; alternatively, call NHS 111 or go directly to your nearest A&E department. Any suspected reactions should be reported through the MHRA Yellow Card scheme, accessible at yellowcard.mhra.gov.uk. Healthcare professionals and patients are encouraged to submit reports to support ongoing pharmacovigilance.
Safety Advice
There are several important safety considerations to be aware of before and during treatment with Super Avana. Please read each section carefully and discuss any concerns with your prescriber.
Drug Interactions
Super Avana is contraindicated with nitrate medicines including:
- Glyceryl trinitrate
- Isosorbide mononitrate
Because the combination can trigger a severe and potentially fatal fall in blood pressure, nitrates prescribed for angina must not be taken alongside this medicine.
It must not be used concurrently with other PDE5 inhibitors, other Dapoxetine-containing products, or strong CYP3A4 inhibitors such as:
- Ketoconazole
- Ritonavir
- Clarithromycin
As these agents significantly increase plasma concentrations of Avanafil.
Combining Dapoxetine with other serotonergic medicines, including:
- SNRIs
- Tricyclic antidepressants
- Tramadol and triptans
All carry a recognised risk of serotonin syndrome when combined with Dapoxetine and must be avoided.
Recreational drugs such as amyl nitrite (poppers) are strictly contraindicated. Always disclose all medicines, herbal supplements, and over-the-counter products to your prescriber and pharmacist before commencing treatment.
Alcohol
Alcohol must be avoided whilst taking Super Avana. The combination of Dapoxetine and alcohol substantially increases the risk of dizziness, orthostatic hypotension, fainting, and impaired coordination. Even moderate alcohol consumption may diminish the clinical efficacy of both active ingredients and heighten the risk of adverse cardiovascular effects.
Medical Conditions to Disclose
Tell your doctor if you have or have had any of the following:
- Cardiovascular disease
- A recent heart attack or stroke; or blood pressure that is either uncontrolled and elevated, or abnormally low
- Hepatic or renal impairment
- A personal or family history of prolonged QT interval
Bleeding disorders, or a mental health condition, including depression or bipolar disorder.
Men with anatomical deformity of the penis or a predisposition to priapism should exercise particular caution.
Pregnancy and Fertility
No clinical data exist to assess its safety during pregnancy. There are no clinical data on use during pregnancy. As this medicine is not intended for women, teratogenicity data are not applicable. However, prescribers should note that Dapoxetine is an SSRI and that relevant reproductive safety considerations apply accordingly.
Dependence Risk
Dapoxetine is not classified as having a potential for dependence under current UK regulatory frameworks. Nonetheless, patients should not exceed the prescribed dose or frequency of administration. Avanafil does not carry a recognised risk of dependence. If you find yourself relying on either component beyond prescribed parameters, discuss this with your healthcare professional.
Driving and Operating Machinery
Dizziness, visual disturbances, and somnolence are possible side effects of Super Avana. Patients should not drive or operate heavy machinery until they are confident this medicine does not impair their ability to do so safely. This is particularly important following the first dose.
Accessing Treatment Responsibly
Super Avana is a prescription-only medicine (POM) in the United Kingdom. Legal supply of this medicine is only possible when a valid prescription has been issued by a registered UK healthcare professional. Obtaining prescription medicines from unregulated or unlicensed online sources carries a serious risk of receiving counterfeit, substandard, or incorrectly dosed products. Speak to your GP, a sexual health clinician, or a registered pharmacist to begin the appropriate clinical pathway. Do not self-prescribe or share prescription medicines with others.
Frequently Asked Questions
Q: Is Avanafil stronger than Viagra?
A: Avanafil is not necessarily stronger than Viagra. However, it acts faster, often within 15 minutes. Greater selectivity in its mechanism means that, for certain men, the likelihood of experiencing side effects may be reduced.
Q: Is Avanafil safe to use?
A: Avanafil is safe for most adult men when prescribed correctly. It must not be taken with nitrates. Always consult a UK-registered healthcare professional before starting treatment.
Q: How long will Avanafil last?
A: Avanafil typically lasts up to six hours. Effects vary between individuals. Sexual stimulation remains necessary for this medicine to work.
Q: Which is better, Tadalafil or Avanafil?
A: Neither is universally better. Tadalafil lasts longer, up to 36 hours. Avanafil acts faster with fewer reported side effects. Your prescriber can advise which suits you best.
Conclusion
Super Avana (Avanafil 100mg + Dapoxetine Hydrochloride 60mg) offers a dual-action pharmacological approach for adult men managing both erectile dysfunction and premature ejaculation. Avanafil enhances penile blood flow through PDE5 inhibition, whilst Dapoxetine modulates the ejaculatory reflex via serotonin reuptake inhibition. Being a prescription-only medicine, it is both prescribed and dispensed exclusively within the regulated clinical framework of the UK. Like any medicine, side effects can occur. The risk of clinically significant drug interactions, particularly with nitrates and serotonergic agents, necessitates full disclosure of all concurrent medicines prior to initiation. Reporting any such reactions through the MHRA Yellow Card scheme is strongly encouraged. Before commencing, adjusting, or stopping this treatment, guidance should always be sought from a qualified UK healthcare professional.
References and Further Reading
NHS — Erectile dysfunction: www.nhs.uk/conditions/erection-problems-erectile-dysfunction
Spedra (Avanafil) Summary of Product Characteristics: www.medicines.org.uk
NICE — Priligy (Dapoxetine) Summary of Product Characteristics: www.nice.org.uk
Medical Disclaimer
This article is for informational purposes only and does not replace professional medical advice. Always consult a qualified healthcare professional registered in the UK before beginning or making any changes to your treatment. Individual medical circumstances vary. Never self-diagnose or self-prescribe based on online information.